NEP1-40; NOGO EXTRACELLULAR PEPTIDE; 1-40
AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2
CAS: 475221-20-6
Molecular Formula: C206H324N56O65
NEP1-40; NOGO EXTRACELLULAR PEPTIDE; 1-40 - Names and Identifiers
NEP1-40; NOGO EXTRACELLULAR PEPTIDE; 1-40 - Physico-chemical Properties
| Molecular Formula | C206H324N56O65 |
| Molar Mass | 4625.11 |
| Solubility | H2O: 1mg/mL |
| Appearance | solid |
| Color | white |
| Storage Condition | -20°C |
| In vivo study | NEP(1-40) (89 μg/kg, ip, 15 min and 19 h post-injury) administration further shifts distributions of microglia away from an injury-induced activated morphology towards greater proportions of rod and macrophage-like morphologies. Animal Model: 74 male Sprague-Dawley rats (328-377 g). Dosage: 89 μg/kg (97.5% PBS and 2.5% DMSO). Administration: IP, 15 min and 19 h post-injury. Result: Reduced NgR function immediately post-injury. Increased number of amoeboid microglia/macrophages at 2 days post-injury |
NEP1-40; NOGO EXTRACELLULAR PEPTIDE; 1-40 - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
NEP1-40; NOGO EXTRACELLULAR PEPTIDE; 1-40 - Reference Information
| biological activity | NEP(1-40) is a peptide antagonist of Nogo-66 receptor (NgR), which reverses the changes in the morphological distribution of microglia caused by damage by inhibiting myelin. |
| in vivo study | NEP(1-40) (89 μg/kg, ip, 15 min and 19 h post-injury) administration further shifts distributions of microglia away from an injury-induced activated morphology towards greater proportions of rod and macrophage-like morphologies. Animal Model: 74 male Sprague-Dawley rats (328-377g). Dosage: 89 μg/kg (97.5% PBS and 2.5% DMSO). Administration: IP, 15 min and 19 h post-injury. Result: Reduced NgR function immediately post-injury. Increased number of amoeboid microglia/macrophages at 2 days post-injury |
| Animal Model: | 74 male Sprague-Dawley rats (328-377 g). |
| Dosage: | 89 μg/kg (97.5% PBS and 2.5% DMSO). |
| Administration: | IP, 15 min and 19 h post-injury. |
| Result: | Reduced NgR function immediately post-injury. Increased number of amoeboid microglia/macrophages at 2 days post-injury |
Last Update：2024-04-09 21:54:55
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View History
NEP1-40; NOGO EXTRACELLULAR PEPTIDE; 1-40
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地塞米松杂质-17-酮
C.I. Developer 20 (Obs.)
噻吩-2-羧酸(3-氨基-苯基)-酰胺
2-溴-1-(4-(嘧啶-2-基)哌嗪-1-基)丁烷-1-酮
Sodium 5-nitroguaiacolate
2-(2-methoxyethoxy)ethanol diethylene glycol monomethyl ether
草质素-7-鼠李糖苷(草质素苷)
地塞米松杂质-17-酮
C.I. Developer 20 (Obs.)
噻吩-2-羧酸(3-氨基-苯基)-酰胺
2-溴-1-(4-(嘧啶-2-基)哌嗪-1-基)丁烷-1-酮
Sodium 5-nitroguaiacolate
2-(2-methoxyethoxy)ethanol diethylene glycol monomethyl ether